Synthesis of some thiazolyl aminobenzothiazole derivatives as potential antibacterial, antifungal and anthelmintic agents

Abstract

A series of 4-(6-substituted-1,3-benzothiazol-2-yl)amino-2-(4-substitutedphenyl)- amino-1,3-thiazoles, 9–24 have been synthesised from 2-chloro-N-(6-substituted-1,3-benzothiazol-2-yl)acetamides, 5–8. The structures of these compounds have been elucidated by spectral (IR, ¹H NMR, Mass) and elemental (C, H, N) analysis data. All the newly synthesised compounds (9–24) were screened for their antibacterial, antifungal and anthelmintic activities. Almost all of these compounds showed moderate to good antimicrobial activity against two gram negative bacteria (E. coli, P. aeruginosa), two gram positive bacteria (S. aureus, B. subtilis), pathogenic fungal strains (C. albicans, A. niger) and good anthelmintic activity against earthworm species (P. corethruses). Compounds 18 and 20 exhibited good antibacterial and antifungal activities, while compound 22 displayed the most significant anthelmintic activity.

Keywords::

• Aminobenzothiazole
• thiazole
• antibacterial activity
• antifungal activity
• anthelmintic activity

Acknowledgements

The authors are thankful to Dr. Bhoomendra Bhongade, International Medical University, Kuala Lumpur, Malaysia for his help and valuable suggestions and SAIL, School of Pharmaceutical Sciences, RGPV, Bhopal for mass spectra and CHN analysis.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.