Synthesis and biological evaluation of fused oxepinocoumarins as free radicals scavengers

Abstract

Some fused dihydrooxepino[f]-, [g]-, and [h]coumarins were obtained from the ring-closing metathesis of the corresponding o-allyl-allyloxycoumarins under the treatment with the first generation Grubbs’ catalyst. These compounds were tested in vitro for their antioxidant activity, and they present significant scavenging activity. They were also showed to inhibit in vitro soybean lipoxygenase.

Keywords::

• Oxepinocoumarins
• allyloxycoumarins
• claisen rearrangement
• ring-closing metathesis
• antioxidant activity

Acknowledgement

We thank Dr C. Hansch and Biobyte Corp. 201West 4th Str., Suite 204, Claremont CA California, 91711, for free access to the C-QSAR program.

Declaration of interest

The authors report no conflict of interest.