Synthesis, characterization and DNA binding and cleavage properties of ruthenium(II) complexes with various polypyridyls

Abstract

Polypyridyl chlororuthenium(II) complexes have been synthesized and characterized. The binding mode of the complexes to DNA has been evaluated from the combined results of electronic absorption spectroscopy and viscosity measurement study. The results suggest that complexes 1, 2 and 3 bind to DNA via classical intercalation, electrostatic interaction and partial intercalation mode, respectively. Complex 2 shows less affinity for DNA. Cleavage of pUC19 DNA by complexes has been checked using gel electrophoresis. The data disclose that complex 1 has the highest cleaving ability.

Keywords::

• Ruthenium(II) complexes
• Polypyridyl
• intercalation
• gel electrophoresis

Acknowledgement

The authors wish to thank Head, Department of Chemistry, and Dr. Thakkar, BRD school of Bioscience, Sardar Patel University, India for making it convenient to work in laboratory and U.G.C. for providing financial support under “UGC Research Fellowship in Science for Meritorious Students” scheme.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.