Metal-based new sulfonamides: Design, synthesis, antibacterial, antifungal, and cytotoxic properties

Abstract

Cobalt(II), copper(II), nickel(II) and zinc(II) metal complexes with 5-chlorosalicyladehyde derived Schiff base sulfonamides have been synthesized and characterized. Structure and bonding nature of all the synthesized compounds have been deduced from physical, analytical, and spectral (IR, ¹H NMR, ¹³C NMR, Mass, electronic) data. An octahedral geometry has been proposed for all the metal complexes. The ligands and their metal complexes have been screened for their in vitro antibacterial, antifungal, and cytotoxic properties and results are reported.

Keywords::

• Sulfonamides
• metal(II) complexes
• antibacterial
• antifungal
• cytotoxic

Acknowledgments

We are indebted to HEJ research Institute of Chemistry, University of Karachi, Pakistan, for providing help in taking NMR, mass spectra, antibacterial and antifungal assays. One of us (HAZ) is grateful to Higher Education Commission (HEC), Government of Pakistan for the award to carry out this research.

Declaration of interest

The authors report no declarations of interest.