Cytotoxicity and DNA interactions of some platinum(II) complexes with substituted benzimidazole ligands

Abstract

In the present study, four Pt(II) complexes with 2-ethyl (1)/or benzyl (2)/or p-chlorobenzyl (3)/or 2-phenoxymethyl (4) benzimidazole carrier ligands were evaluated for their in vitro cytotoxic activities against the human HeLa cervix, oestrogen receptor-positive MCF-7 breast, and oestrogen receptor-negative MDA-MB 231 breast cancer cell lines. The plasmid DNA interactions and inhibition of the BamHI restriction enzyme activities of the complexes were also studied. Complex 3 was found to be more active than carboplatin for all examined cell lines and comparable with cisplatin, except for the HeLa cell line.

Keywords::

• Benzimidazole
• platinum(II) complexes
• cytotoxic activity
• DNA binding
• gel electrophoresis

Acknowledgement

We would like to thank the Research Foundation of Gazi University (02/2007-16) for financial support.

Declaration of interest

Financial support of this work (02/2007-16) by the Research Foundation of Gazi University is gratefully acknowledged.