Synthesis and antidiabetic activity of morpholinothiazolyl-2,4-thiazolidindione derivatives

Abstract

We report the synthesis and the in vitro insulin releasing and glucose uptake activity of the morpholino thiazolyl-2,4-thiazolidinediones (1-15). Compounds 5, 11–15 (at lower concentration; 0.001 mg/ml) were able to increase insulin release in the presence of 5.6 mmol/l glucose. The compounds, except derivative 3 show an increase of glucose uptake. Various compounds are interesting potential antidiabetic leads showing pancreatic and extrapancreatic effects.

Keywords::

• Antidiabetic drugs
• 2;4-thiazolidinediones
• thiazolyl-2;4-thiazolidinediones
• insulinotropic activity
• glucose uptake

Acknowledgement

This work was supported by Research Organization of Ankara University, Turkey (No: 09B3336003) and Hacettepe University Syntific Research Department (Project number: 04A602004). The skillful help undergraduate Ummu Duzgun.

Declaration of interest

The authors report no conflicts of interest.