Synthesis and antibacterial activity of novel 4-chloro-2-mercaptobenzenesulfonamide derivatives

Abstract

Few series of novel 4-chloro-2-mercaptobenzenesulfonamides have been synthesized by the reactions of N-(benzenesulfonyl)cyanamide potassium salts 7–15 with corresponding hydrazinecarbodithioic acid esters, 1-substituted carbothioic acid hydrazides, methyl 3-aminothiophene-2-carboxylate, methyl 2-aminobenzoate, 2-aminophenol or 2-aminothiophenol. The synthesized compounds (16–49) were screened in vitro for their antibacterial activity. Some of the tested compounds 16, 17, 23, 24, 31, 32 and 48 showed the promising activity against many of anaerobic Gram-positive bacteria strains.

Keywords::

• 2-mercaptobenzenesulfonamide
• antibacterial
• anti-tumour
• synthesis
• 1,3,4-thiadiazole

Acknowledgements

The authors are very grateful to Dr. Joel Morris, Ph.D., Chief Drug Synthesis & Chemistry Branch, National Cancer Institute (Bethesda, MD) for the in vitro anticancer screening.

Declaration of interest

The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.