Abstract
Some new 7-substituted-phenyl-3,4,8,9-tetrahydro-2H-pyridazino[1,6-a][1,3,5]triazin-2-imine/one/thione derivatives were synthesized by a sequence of reactions starting from appropriate aryl hydrocarbons. The final compounds were screened for antihypertensive activities by non-invasive method using Tail Cuff method. All the test compounds showed significant antihypertensive activity; 7-(biphenyl-4-yl)-3,4,8,9-tetrahydro-2H-pyridazino[1,6-a][1,3,5]triazin-2-imine (4p) exhibited antihypertensive activity more than the reference standard drugs.
Acknowledgements
The authors are also thankful to Jamia Hamdard, New Delhi, India for providing facility for the research work.
Declaration of interest
Ravinesh Mishra expresses sincere thanks to the University Grant Commission (UGC), New Delhi, India, for the award of Research Fellowship in Science for Meritorious Students (RFSMS).