Abstract
The condensation reaction of 3,5-diamino-1,2,4-triazole with methoxy-, chloro-, bromo-, iodo- and nitro-substituted 2-hydroxybenzaldehydes formed triazole Schiff bases (L1)–(L6). The synthesized ligands have been characterized through physical, spectral and analytical data. Furthermore, the reaction of synthesized Schiff bases with the oxovanadium(IV) sulphate in (1:2) (metal:ligand) molar ratio afforded the oxovanadium(IV) complexes (1)–(6). All the complexes were non-electrolytic and showed a square-pyramidal geometry. The synthesized compounds have been screened for in-vitro antibacterial, antifungal and brine shrimp bioassay. The bioactivity data showed the complexes to be more active than the original Schiff bases.
Acknowledgments
The authors are thankful to Higher Education Commission (HEC), Government of Pakistan for the award to carry out this research work. We are also indebted to HEJ research Institute of Chemistry, University of Karachi, Pakistan, for providing their help in taking NMR and mass spectra and, for the help in carrying out antibacterial, antifungal and brine shrimp bioassays.