Microwave-assisted synthesis of antimicrobial agents based on pyridazine moiety

Abstract

An efficient and simple microwave assisted synthesis of sulfonamide derivatives incorporating the pyridazine moiety has been developed. These sulfonamides were used for the preparation of new heterocyclic compounds via reaction with different reagents using a microwave irradiation technique. The structures of the newly synthesized compounds were confirmed on the basis of FTIR, ¹H and ¹³C-NMR, mass spectral techniques and elemental analyses. Some of the new synthesized compounds were assayed for their in vitro antibacterial activity against Gram-positive bacteria, Staphylococcus aureus and Staphylococcus epidermidis, Gram-negative bacteria, Escherichia coli and Klebsiella pneumonia and antifungal activity against Aspergillus fumigatus and Candida albicans. Most of the new compounds showed significant antibacterial and antifungal activity.

Keywords::

• Sulfonamide derivatives
• pyridazine
• antibacterial
• antifungal
• microwave irradiation

Acknowledgement

The authors are indebted to Dr. Nashwa A. Ahmed, Basic Science Department, Faculty of Applied Medical Science, October City, Egypt for help with antimicrobial activity measurements. The authors alone are responsible for the content and writing of the article.

Declaration of Interest: The authors report no conflict of interest.