New barbiturates and thiobarbiturates as potential enzyme inhibitors

Abstract

A series of 27 new barbiturates and thiobarbiturates have been synthesized by a convenient multi-component reaction in overall excellent yields (87–96%). All the synthesized compounds were characterized by 1H, 13C NMR, EIMS and elemental analysis (C, H, N and S). Furthermore, all compounds were screened for in vitro antioxidant (DPPH radical scavenging), lipoxygenase, chymotrypsin, α-glucosidase and anti-urease activities. Out of the series, 23 in DPPH, 14 in lipoxygenase, 2 in chymotrypsin have shown appreciable IC₅₀ values.

• α-Glucosidase and anti-urease
• antioxidant (DPPH radical scavenging)
• barbituric acid
• chymotrypsin
• lipoxygenase
• thiobarbituric acid
• thiosemicarbazone

Declaration of interest

There is no declaration of interest. One of the authors Saira Mumtaz likes to acknowledge Higher Education Commission of Pakistan for providing funding and support throughout this study.

Supplementary material available online

Supplementary materials