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Abstract
This paper is a review of the work of my former academic group of research in the past 15 years, in the field of cognition enhancers (also called nootropics) that identified two very potent molecules: Unifiram and Sunifiram that for a variety of reasons were not protected by a patent. Some 12 years after their disclosure (2000) I casually found that on the web, there were dozens of sites offering Unifiram and Sunifiram as drugs that improve cognition in healthy individuals even if only few preclinical studies were done and their long-term toxicity was unknown.
Acknowledgements
I wish to dedicate this work to my former staff with particular acknowledgement to Serena Scapecchi who departed us too early, and to all the scientists that have contributed to its success.
Medicinal chemists
Staff: Cristina Bellucci, Silvia Dei, Dina Manetti, Maria Novella Romanelli, Serena Scapecchi, and Elisabetta Teodori.
PhD students and post doc: Luca Guandalini, Cecilia Martelli, Elisabetta Martini, Michele Melchiorre, and Simona Pagella.
Chemists: Gianluca Bartolucci and Carlo Bertucci.
Pharmacologists: Alessandro Bartolini, Elisabetta Baldi, Corrado Bucherelli, Nicoletta Galeotti, Carla Ghelardini, Monica Norcini, Anna Pittaluga, Annamaria Pugliese, and Alberto Salvicchi.
Many thanks to my daughter-in-law Montine Blank who revised the paper, fixing my broken English.
Declaration of interest
The author reports no conflicts of interest. The author alone is responsible for the content and writing of this article.
Supplementary material available online.
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