Synthesis and anticandidal evaluation of new benzothiazole derivatives with hydrazone moiety

Abstract

In this study, we have performed the synthesis of new N′-(arylidene)-4-[(benzothiazol-2-yl)thio]butanoylhydrazide derivatives (3a–s) bearing azole moiety and hydrazone group in a lipophilic structural framework. The target compounds were prepared by a three step synthetic procedure starting from 2-mercaptobenzothiazole. The structures of the target compounds were elucidated by IR, ¹H NMR, ¹³C NMR spectra and elemental analysis. The antifungal activity of the obtained compounds has been determined against a number of clinic and fluconazole-resistant Candida strains by using microdilution method. Compounds (3a–3s) exhibited anticandidal activity in different ratios varying between the range of MIC: 50 and 200 µg/mL.

• 2-Mercaptobenzothiazole
• anticandidal
• antifungal
• hydrazone

Declaration of interest

The authors declare that this article content has no conflict of interest.

This study was supported within the Anadolu University Scientific Research Project, Eskişehir, Turkey (Project no: 1406S066).

Supplementary material available online