Effective treatment of Hailey–Hailey disease with a long-pulsed (5 ms) alexandrite laser

Abstract

Familial benign pemphigus (Hailey–Hailey disease) is often resistant to conventional treatments. This report describes a 35-year-old Asian American male with a 12-year history of recalcitrant Hailey–Hailey disease who was treated with a long-pulsed alexandrite laser. Fluences ranged from 12 to 20 J/cm with a 5-ms pulse duration (spot sizes: 10–15 mm). Cold air cooling was used during the sessions. There was 50% improvement noted after the first treatment. Within 10 treatments, there was 95% clearance. Complete resolution was achieved by the thirteenth treatment. The lesions have been clear or nearly clear (greater than 95%) for the past 2 years. Once clearance was achieved, five maintenance laser treatments were initiated at 3-month intervals and eventually discontinued for 12 months without relapse.

Key Words::

• acantholysis
• alexandrite
• ATP2C1
• familial benign pemphigus
• Hailey–Hailey disease
• lasers

Acknowledgement

The authors would like to acknowledge and thank David T. Woodley, MD, Chairman of the Dermatology Department, Keck/USC School of Medicine, for his assistance in preparing this manuscript.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.