Failure of cervical ripening with prostaglandin-E2 can it be predicted?

Abstract

Objective. To identify factors predicting failure of cervical ripening with prostaglandin E₂ (PGE₂).

Study design. A retrospective, cohort study of all women admitted for preinduction cervical ripening and failed to respond to PGE₂ in comparison with randomly selected control group of women who underwent successful preinduction cervical ripening with PGE₂ in a 3:1 ratio.

Results. Overall 488 women were included, of them, 122 in the study group and 366 in the control group. A comparison between the two groups has revealed that maternal age above 30 years (OR = 2.7, 95%-CI 1.3–5.6), nulliparity (OR = 4.1, 95%-CI 1.7–10.0), prepregnancy BMI above 25 kg/m² (OR = 3.5, 95%-CI 1.7–7.1), cervical dilatation of 1 cm (OR = 9.1, 95%-CI 3.5–13.4), cervical effacement of 50% or less admission (OR = 5.0, 95%-CI 2.2–8.8), and gestational age of 37 weeks or less (OR = 2.9, 95%-CI 1.3–6.6), are independent and significant predictors of cervical ripening failure with PGE₂, and account for almost 50% of the variation in ripening outcome (R² = 0.47). No association was found between the risk of cervical ripening failure and the indication for ripening, rupture of membranes, weight gain during pregnancy, weight before labor, diabetes or preeclampsia during pregnancy, and the newborn weight.

Conclusions. Characterization of women who have a high probability for cervical ripening failure with PGE₂ will help to improve consultation and may help choosing the optimal method for labor induction in these cases.

Keywords:

• Prostaglandin
• PGE₂
• ripening
• induction
• failure

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.