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Case Reports

Anaphylactic shock due to hepatitis B immunoglobulin in a newborn

, , , &
Pages 1257-1259 | Received 13 Nov 2009, Accepted 22 Jan 2010, Published online: 09 Mar 2010
 

Abstract

Hepatitis B immunoglobulin (HBIG) is administered for the passive immunisation of all infants born to HBsAg-positive mothers within 12 h of birth. Adverse effects of HBIG are very rare. In this study, we report a newborn (a female, 33 weeks' gestation and 2030 g birth weight) developing anaphylaxis after HBIG administration. The mother was a Hepatitis B virus (HBV) carrier. Hypotension and erythematous rash developed 7 min after HBIG administration. Reporting the first anaphylaxis case in newborns due to HBIG in literature, we suggest the condition be taken into account, and requisite precautions should be taken against this probable complication in the newborn.

Declaration of interest: The authors have indicated they have no conflict of interest and financial relationships relevant to this article to disclose.

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