Relationship between oxidant and antioxidant activity in hyperemesis gravidarum

Abstract

Objective: To evaluate oxidant and antioxidant activity in patients with hyperemesis gravidarum (HG) by using serum total antioxidant activity (TAO), total free sulfhydryl (–SH), ceruloplasmin and lipid hydroperoxide (LOOH) levels.

Materials and methods: In a cross-sectional trial, blood samples were collected from patients with HG (n = 25) and healthy pregnant women (n = 25) as control group. Serum TAO activities, –SH levels and LOOH levels and ceruloplasmin levels were measured.

Results: Serum TAO activity was found to be significantly lower (p = 0.003) in patients with HG compared with controls. However, serum –SH levels, LOOH levels and ceruloplasmin levels did not change significantly in patients with HG compared to controls.

Conclusion: Presence of oxidative stress in HG patients depends more on reduced antioxidant activities than increased oxidative stress.

• Antioxidant activity
• hyperemesis gravidarum
• pregnancy