Little beneficial effect of maternal vitamin supplement on metabolic disturbances in the offspring from the obese mother mice

Abstract

Objective: To examine whether vitamin supplement before and during pregnancy alters the detrimental effect of maternal obesity on the offspring.

Methods: Obese C57BL/6 female mice were randomly divided into four groups and fed with the control, vitamin D, folic acid or multivitamin supplement diet before and during pregnancy. Physiologic and biochemical variables were obtained.

Results: No significant differences were observed in glucose and lipid variables among offspring from each maternal obese group.

Conclusions: Overall, vitamin D, folic acid or multivitamin supplement cannot ameliorate the detrimental effect of maternal obesity on the metabolic disturbances in the offspring.

• Diabetes
• folic acid
• insulin resistance
• lipid disorder
• transgenerational effect
• vitamin D

Declaration of interest

The authors declare no conflict of interest. This study is supported by grants from the National Natural Science Foundation of China (No. 81130049) and National High Technology Research and Development Program of China (No. 2012BAI02B02).