Dose-Response Effects of Intravenous Meperidine on Uterine Activity

Roy H. Petrie Section of Perinatal Obstetrics, Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, New York; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, School of Medicine, University of Southern California, Los Angeles, California; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri

Sze-ya Yeh Section of Perinatal Obstetrics, Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, New York; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, School of Medicine, University of Southern California, Los Angeles, California; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri

Bruce A. Barron Section of Perinatal Obstetrics, Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, New York; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, School of Medicine, University of Southern California, Los Angeles, California; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri

Erol Amon Section of Perinatal Obstetrics, Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, New York; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, School of Medicine, University of Southern California, Los Angeles, California; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri

Ming-ying Gai Department of Obstetrics and Gynecology, Capitol Hospital, Beijing, People's Republic of China

Ling Xu Department of Obstetrics and Gynecology, M.C.H. Hospital, Xian, Shaanxi, People's Republic of China

Jia-zhi Shan Shandong Provincial Hospital, Department of Obstetrics and Gynecology, Jinan, Shandong, People's Republic of China

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Abstract

Uterine activity in the active phase of labor is evaluated in demographically similar groups of patients for the effects of the intravenous administration of 25, 50, 75, and 100 mg of meperidine. Drug effect was evaluated by quantitation of the area under the uterine contraction curve into uterine activity units (torr minutes). Unmedicated uterine activity in the active phase of labor increases by 5 uterine activity units each 10 min of labor. Although considerable individual patient variation exists, each of the four drug groups demonstrated a decrease in uterine activity as compared to expected values for unmedicated labor, and this effect was temporally dependent on dose.

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Dose-Response Effects of Intravenous Meperidine on Uterine Activity

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Dose-Response Effects of Intravenous Meperidine on Uterine Activity

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