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Abstract
Objective: The authors assessed the effectiveness of therapy, common features of pure-tone audiograms, and results of non-invasive electrocochleography before and after mild inhibition of peripheral vestibular function by infrequent administration of single intratympanic gentamicin injections (ITPG) in patients with Ménière's disease (MD). Study sample: Sixty-two patients with Ménière's disease. Design: Retrospective study. Results: Out of 62 patients 65% received one injection, 24% two, 6% three, 3% five, and 2% six injections. Between injections, class A vertigo control was obtained after two weeks in all cases. Before ITPG, out of 62 pure-tone threshold audiograms 37 were ‘flat’. Average hearing threshold at 2 kHz was significantly better than that of 250, 500, and 0.75 kHz on the affected side. Conclusions: Hearing threshold in advanced MD is often flat with a characteristic small peak in the high frequency range, most frequently around 2–3 kHz. Should the complaints be intolerable, single injection ITPG-therapy may be safe and effective.
Acknowledgements
The authors would like to express their gratitude to András Spät and György Füst for their continuing support as excellent teachers.
Declaration of interest: The authors report no declarations of interest.