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Articles

Biological effects of static electric field: Plasma/serum proteome analysis of rats

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Pages 79-94 | Received 13 Feb 2012, Accepted 29 Jun 2012, Published online: 09 Oct 2012
 

Abstract

The external static electric field (SEF) of man-made origin brings to the substantially increased SEF background in a human environment the biological activity of which is a moot question. The paper reports on rats blood plasma/serum proteome modifications by means of 1D polyacrilamide gel electrophoresis and clotting process alterations after the short- and long-term SEF exposures of 200 kV/m. The results indicate decrease of fast α1 and α2 globular proteins in plasma coinciding with clotting acceleration after the short-term SEF, and attenuation of clotting-dependent proteome modifications reflected with incomplete coagulation after the long-term SEF exposure. Increased lysozyme activity in serum unlike plasma was observed after both SEF exposures. Applied model of the high-voltage SEF environment indicates dependence of biological systems functioning on the external SEF.

Acknowledgements

The authors are grateful to Sona Mardanyan and Vardan Gasparyan for critical reading of the manuscript, and to Armine Hakopyan for language corrections.

Declaration of interest This Research Project was sponsored by the State Committee of Science, Ministry of Education and Science of Armenia and local resources of Yerevan State Medical University after Mkhitar Heratsi in the form of a common salary paid to the authors providing necessary devices and reagents. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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