3,582
Views
132
CrossRef citations to date
0
Altmetric
Review Articles

Oxidative mechanisms of biological activity of low-intensity radiofrequency radiation

, , , , &
Pages 186-202 | Received 10 Jan 2015, Accepted 12 Apr 2015, Published online: 07 Jul 2015
 

ABSTRACT

This review aims to cover experimental data on oxidative effects of low-intensity radiofrequency radiation (RFR) in living cells. Analysis of the currently available peer-reviewed scientific literature reveals molecular effects induced by low-intensity RFR in living cells; this includes significant activation of key pathways generating reactive oxygen species (ROS), activation of peroxidation, oxidative damage of DNA and changes in the activity of antioxidant enzymes. It indicates that among 100 currently available peer-reviewed studies dealing with oxidative effects of low-intensity RFR, in general, 93 confirmed that RFR induces oxidative effects in biological systems. A wide pathogenic potential of the induced ROS and their involvement in cell signaling pathways explains a range of biological/health effects of low-intensity RFR, which include both cancer and non-cancer pathologies. In conclusion, our analysis demonstrates that low-intensity RFR is an expressive oxidative agent for living cells with a high pathogenic potential and that the oxidative stress induced by RFR exposure should be recognized as one of the primary mechanisms of the biological activity of this kind of radiation.

Acknowledgments

The authors are grateful to the unknown referees for the valuable comments on the first version of the manuscript.

Declaration of interest

The authors declare no conflicts of interest. This study was supported by National Academy of Sciences of Ukraine (I.Y., E.S.) and by University of Campinas via PPVE (Programa Professor Visitante do Exterior), Brazil (S.K.).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.