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Abstract
The objective of the present study was to evaluate hepatoprotective activity of methanolic extract of Hiptage bengalensis (L.) kurz (MEHB) in rats. Hepatic damage was induced by administration of carbontetrachloride(1 ml/kg, b.w, p.o.) in combination with liquid paraffin (1:1) as a single dose on 7th day. The extent of liver damage was studied by estimating biochemical parameters. Administration of MEHB (200 mg & 400 mg/kg) for 6 days before carbontetrachloride administration showed a significant reduction (p < 0.01) of serum liver damage enzymes markers-aspartate transaminase, alanine transaminase, total bilirubin and alkaline phosphatase (ALP). Histopathological changes of hepatic tissue were also evaluated in control and MEHB treated groups. Results also indicated that MEHB possessed potential antioxidant effect by increasing the levels of glutathione and also possessed free radical scavenging activities. The hepatoprotective effect of Hiptage bengalensis (L.) kurz was comparable to standard drug silymarin (50 mg/kg).
Acknowledgements
All authors are gratefully indebted to Dr. G. Sreenivas Reddy, Secretary, Vaageswari College of Pharmacy Karimnagar, for providing necessary facilities to carry out my project work in time and his constant support and encouragement. First author is thankful to Dr. G. Anand, (Pathologist), Prathima Institute of Medical Sciences, Karimnagar, for providing histopathological reports and his kind help for successful completion of this work.
Declaration of interest
All the authors state that no conflict of interest