Directed Stem Cell Differentiation: The Role of Physical Forces

Abstract

A number of factors contribute to the control of stem cell fate. In particular, the evidence for how physical forces control the stem cell differentiation program is now accruing. In this review, the authors discuss the types of physical forces: mechanical forces, cell shape, extracellular matrix geometry/properties, and cell-cell contacts and morphogenic factors, which evidence suggests play a role in influencing stem cell fate.

Keywords::

• cell-cell contacts
• cell shape
• differentiation
• ECM properties
• geometric controls
• mechanical force
• morphogenic factors

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.