Spontaneous Regression of Congenital Cutaneous Histiocytosis X: Report of a Case with Discussion of Nosology and Pathogenesis

Abstract

Spontaneous regression of histiocytosis X is a rare biologic event as judged by the extensive recorded experience in the literature. We present a case of congenital cutaneous histiocytosis X that resolved without specific therapy in the first week of life. Histologic and ultrastructural studies confirmed the interpretation. This child is an example of so-called pure cutaneous histiocytosis, which, like the other unisystem forms of the disorders, has an excellent prognosis.

Key Words:

• histiocytosis X
• Langerhans cells
• Birbeck granules
• skin