Histiocytosis X Langerhans Cells React with Antiinterleukin-2 Receptor Monoclonal Antibody

Sylvette Barbey Groupe de Pathologie Pédiatrique, Hôpital Necker Enfants Malades, 149, rue de Sèvres 75743, Paris Cedex 15, France

Pierre Gane Centre National de Transfusion Sanguine Hôpital Saint Antoine, 184, Faubourg Saint Antoine 75571, Paris Cedex 12, France

Odile Le Pelletier Centre National de Transfusion Sanguine Hôpital Saint Antoine, 184, Faubourg Saint Antoine 75571, Paris Cedex 12, France

Christian Nezelof Groupe de Pathologie Pédiatrique, Hôpital Necker Enfants Malades, 149, rue de Sèvres 75743, Paris Cedex 15, France

Abstract

Immunohistochemical study of 7 cases of histiocytosis X (HX) and of histologically normal skin shows that HX Langerhans cells react with Bl.49.9 monoclonal antibody which recognizes the Interleukin-2 receptor, whereas normal skin Langerhans cells do not. This reactivity suggest activation of HX Langerhans cells.

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Histiocytosis X Langerhans Cells React with Antiinterleukin-2 Receptor Monoclonal Antibody

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Histiocytosis X Langerhans Cells React with Antiinterleukin-2 Receptor Monoclonal Antibody

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