Fetal Distribution of Cocaine: Case Analysis

J. Klein Motherisk Program, Division of Clinical Pharmacology and Toxicology, Departments of Pediatrics and Pathology and Research Institute, The Hospital for Sick Children, Toronto, M5G 1X8; Department of Pediatrics, York Finch Hospital, Toronto, Ontario, Canada; Departments of Pediatrics, Pharmacology and Pathology, The University of Toronto, Toronto, Ontario, Canada

M. Greenwald Motherisk Program, Division of Clinical Pharmacology and Toxicology, Departments of Pediatrics and Pathology and Research Institute, The Hospital for Sick Children, Toronto, M5G 1X8; Department of Pediatrics, York Finch Hospital, Toronto, Ontario, Canada; Departments of Pediatrics, Pharmacology and Pathology, The University of Toronto, Toronto, Ontario, Canada

L. Becker Motherisk Program, Division of Clinical Pharmacology and Toxicology, Departments of Pediatrics and Pathology and Research Institute, The Hospital for Sick Children, Toronto, M5G 1X8; Department of Pediatrics, York Finch Hospital, Toronto, Ontario, Canada; Departments of Pediatrics, Pharmacology and Pathology, The University of Toronto, Toronto, Ontario, Canada

G. Koren Motherisk Program, Division of Clinical Pharmacology and Toxicology, Departments of Pediatrics and Pathology and Research Institute, The Hospital for Sick Children, Toronto, M5G 1X8; Department of Pediatrics, York Finch Hospital, Toronto, Ontario, Canada; Departments of Pediatrics, Pharmacology and Pathology, The University of Toronto, Toronto, Ontario, Canada

Abstract

The implications of gestational cocaine use are widely documented. There is evidence that cocaine crosses the placenta in animals and humans; however, the fetal distribution of the drug and its metabolites has not been documented. We describe the distribution of cocaine and benzoylecgonine (BE) in the fetus of a cocaine user mother. Cocaine and BE were detected in brain, scalp, liver, kidney, heart, placenta, blood, and hair. The liver contained substantially more cocaine than other tissues, whereas the brain had more BE than any other sample.

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Fetal Distribution of Cocaine: Case Analysis

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Fetal Distribution of Cocaine: Case Analysis

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