Stability of Twenty-Five Analytes in Human Serum at 22d`C, 4d`C, and -20d`C

James G. Donnelly Institute for Biomolecular Studies and Department of Biology, The Catholic University of America, Washington, DC, USA

Steven J. Soldin Department of Laboratory Medicine, Children's National Medical Center, Washington, DC, USA; Departments of Pediatrics and Pathology, The George Washington University, Washington, DC, USA

Daniel A. Nealon Release Systems Testing Group, Johnson & Johnson Clinical Diagnostics, Rochester, New York, USA

Jocelyn M. Hicks Department of Laboratory Medicine, Children's National Medical Center, Washington, DC, USA; Departments of Pediatrics and Pathology, The George Washington University, Washington, DC, USA

Abstract

The stability of 25 analytes from serum of healthy donors was determined at room temperature, 4d`C, and -20d`C over 48 h, 14 days, and 4 months, respectively. Glucose, blood urea nitrogen, sodium, potassium, chloride, creatinine, calcium, phosphorus, uric acid, total protein, albumin, triglycerides, lipase, total creatine kinase, gamma-glutamyltransferase, iron, magnesium, and cholesterol were stable at all three temperatures for the specified times. Carbon dioxide, aspartate and alanine aminotransferases, lactate dehydrogenase, analyse, alkaline phosphatase, and high-density lipoprotein cholesterol demonstrated some loss over time. Proper storage temperatures and times must be considered for these analytes if measurement is not to take place immediately after specimen collection.

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Stability of Twenty-Five Analytes in Human Serum at 22d`C, 4d`C, and -20d`C

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Stability of Twenty-Five Analytes in Human Serum at 22d`C, 4d`C, and -20d`C

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