Contact dermatitis caused by dimethylfumarate in Argentina

July 2011, Vol. 49, No. 6 , Pages 508-509 (doi:10.3109/15563650.2011.594800)
1Centro de Investigaciones Toxicológicas,
Juan B. Alberdi 2986, Ciudad de Buenos Aires
, Argentina
2Instituto Antártico Argentino,
Cerrito 1248, Ciudad de Buenos Aires
, Argentina
3Cátedra de Biotecnología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina
Address correspondence to Alfredo Lo Balbo, Centro de Investigaciones Toxicológicas,
Avenida Juan Bautista Alberdi 2986, 1406 Ciudad de Buenos Aires
, Argentina. Tel: 5411-4613-1100. E-mail:



For the first time in Argentina, we describe an outbreak of contact dermatitis. New pairs of shoes caused intense pruritus, pain, and eruption, followed by edema, blisters, and a severe negative impact on the epidermal barrier of the feet. We identify dimethylfumarate as the causal agent and suggest an analytical method for its fast identification.