Hemodialysis Clearance and Total Body Elimination of Carbamazepine during Chronic Hemodialysis

C. S. Lee Department of Pharmaceutics College of Pharmacy, University of Florida, Gainesville, Florida, 32610

L. H. Wang Department of Pharmaceutics College of Pharmacy, University of Florida, Gainesville, Florida, 32610

T. C. Marbury Department of Renal Medicine College of Medicine, University of Florida, Gainesville, Florida, 32610

J. Bruni Department of Neurology College of Medicine, University of Florida, Gainesville, Florida, 32610

R. J. Perchalski Department of Neurology College of Medicine, University of Florida, Gainesville, Florida, 32610

Abstract

The effect of the aritficial kidney on the removal of carbamazepine was studied in four uremic patients undergoing chronic hemodialysis. Each patient received 500 mg of carbamazepine PO 8 hr prior to hemodialysis. Predialysis and postdialysis blood samples as well as dialysate samples were collected at various time intervals during a 4-hr hemodialysis.

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Hemodialysis Clearance and Total Body Elimination of Carbamazepine during Chronic Hemodialysis

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Hemodialysis Clearance and Total Body Elimination of Carbamazepine during Chronic Hemodialysis

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