In Vitro Binding characteristics for cesium of two qualities of prussian blue, activated charcoal and Resonium-A

Abstract

The in vitro binding characteristics of radioactive ¹³⁷Cs to two forms of Prussian blue {colloidally (soluble) K3Fe[Fe(CN)6] and insoluble Fe4[Fe(CN)6]3} and to activated charcoal and sodium polystyrene sulfonate (Resonium-A) were investigated by constructing Langmuir isotherms at pH = 1.0, 6.5 and 7.5 at 37°C. At the three pHs investigated, ¹³⁷Cs binding to activated charcoal and sodium polystyrene sulfonate was negligible. Binding of ¹³⁷Cs to insoluble Prussian blue exceeded that for the soluble form and was pH dependent for both formulations. Maximum binding capacities were 87 mg/g (pH = 1.0), 194 mg/g (pH = 6.5) and 238 mg/g (pH = 7.5) for the insoluble form and 48 (pH = 1.0), 73 (pH = 6.5) and 78 (pH = 7.5) for the soluble form. As activated charcoal did not bind ¹³⁷Cs, charcoal hemoperfusion is of no value. This has been confirmed by an in vitro experiment, using a Gambro Adsorbs 300 C cartridge.

KEY WORDS:

• radioisotopes, binding
• ¹³⁷Cs
• radiocesium
• ferric ferrocyanide, CAS 14038-43-8
• potassium ferricyanide, CAS 13746-66-2
• sodium polystyrene sulfonate
• charcoal