Loxoprofen — Another Nsaid Associated with Acute Asthmatic Death

Toshifumi Watanabe Department of Legal Medicine, Sapporo Medical College, Sapporo, Japan

Masakatsu Sakata Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University, Tobetsu, Ishikari, Japan

Ritsuko Shimabukuro Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University, Tobetsu, Ishikari, Japan

Kumiko Sakata Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University, Tobetsu, Ishikari, Japan

Noriko Tabata Department of Legal Medicine, Sapporo Medical College, Sapporo, Japan

Jun-Ichi Azumi Department of Legal Medicine, Sapporo Medical College, Sapporo, Japan

Masahiko Morita Department of Legal Medicine, Sapporo Medical College, Sapporo, Japan

Koichi Itaya Division of Hospital Pharmacy, Sapporo Medical College, Sapporo, Japan

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Abstract

Loxoprofen sodium (sodium 2[4-(2-oxocyclopentylmethyl) phenyl] dehydrate; CAS #68767—14—6) is a nonsteroidal, inflammatory drug marketed only in Japan. A case report describes its association with an acute asthmatic death with features resembling those evoked by similar drugs. The analytic methodology is reported. The blood levels of loxoprofen were in the therapeutic range. The tissue concentrations are reported.

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Loxoprofen — Another Nsaid Associated with Acute Asthmatic Death

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Loxoprofen — Another Nsaid Associated with Acute Asthmatic Death

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