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Abstract
Objective: To report plasma moclobemide, course and outcome of two cases of overdose with moclobemide alone and one case of combined ingestion of moclobemide and clomipramine. Methods: Moclobemide identification and quantification was achieved by gas chromatography-mass spectrometry after alkaline extraction. Case Reports: In case 1, plasma moclobemide was 2.8 mg/L with 1.8 mg/L clomipramine; in case 2, 18 mg/L; in case 3, 60.9 mg/L and 4.6 mg/L 12 hours later. None of the patients showed serious effects during 24 hours of observation. Plasma moclobemide at 10 to 30 x therapeutic was not associated with major toxic effects. Moclobemide seems to be considerably less toxic than tricyclic antidepressants.