Accidental Ingestion of a Zinc and Copper Sulfate Preparation

Abstract

Case Report: An 86-year-old woman accidentally ingested a preparation containing zinc and copper sulfate. At ninety minutes after ingestion, the peak plasma concentration was 1979 μg/dL for zinc and 209 μg/dL for copper, suggesting preferential absorption of zinc. The major complications were gastric and bronchial inflammation due to the corrosive properties of these compounds. Systemic manifestations also developed with cardiovascular failure and renal insufficiency, but the patient made a complete recovery. In addition to symptomatic treatment, chelation therapy with dimercaprol and D-penicillamine was given for 48 h. Conclusion: The available clinical and toxicokinetic data do not support the benefits of chelation in addition to supportive therapy.