Allopurinol hypersensitivity syndrome with acute generalized exanthematous pustulosis manifestations

Abstract

Allopurinol hypersensitivity syndrome(AHS) is a severe form of cutaneous adverse reaction that is associated with significant morbidity and mortality. We report a case of AHS with the cutaneous manifestation of acute generalised exanthematous pustulosis(AGEP). A 47 year old gentleman, with no previous skin disease, presented with a generalized mildly pruritic erythematous rash on the trunk and all 4 limbs, with patches of superficial non-follicular pustules. Our patient fulfilled both criteria for AGEP and AHS.

Keywords::

• Hypersensitivity
• AGEP
• allopurinol

Acknowledgements

The authors would like to acknowledge Dr Michelle Chan of the Pathology Department, Singapore General Hospital for her kind assistance with reproduction of the histopathology slides.

Declaration of interest

The authors report no declarations of interest. The authors are responsible for the content and writing of this manuscript.