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Abstract
Abrading the skin of guinea pigs was investigated as a method to enhance the sensitivity of a topical occlusive method for detecting potential contact sensitizers. Three studies were conducted using isoeugenol in petrolatum as the sensitizer.
In each of the studies, the concentration of isoeugenol that produced strong irritation to nonabraded skin during induction produced the strongest sen-sitization reactions at the challenge applications. Of the groups induced with the highest nonirritating concentration of isoeugenol, the incidence and severity of reactions were highest overall in the abraded animals.
The results of these studies suggest that abrading the skin may increase the sensitivity of the closed patch guinea pig test procedure by enhancing skin penetration of the sensitizing agent.