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Abstract
Two antecubital wash protocols were compared by testing a syndet bar and a moisturizer. The results show that the irritation potential predicted for a material is highly dependent on the conditions under which it is tested. It is possible to generate irritation far in excess of what would be expected under normal use, even for a product with skin-healing effects, by using aggressive exposure conditions. The results highlight a need to employ exposures representative of the anticipated use conditions and to interpret results in the context in which they are generated to avoid drawing incorrect conclusions about a material's in-use irritancy.