Evaluation of Skin Sensitization and Cross-Reaction of Nine Alkyleneamines in the Guinea Pig Maximization Test

Abstract

A group of nine alkyleneamines were investigated for their potential to induce skin sensitization and to cross-react with one another to elicit a hypersensitivity response. Ethylenediamine was the most potent skin sensitizer, and diethylenetriamine was next in potency. The sensitizing potency was inversely correlated with the number of amine units. Cyclic amines such as piperazine had a lower sensitizing potency than the corresponding olefinic amines. Ethylenediamine also produced the strongest response in cross-reactions with other alkyleneamines. The results suggest that there was a direct correlation of the potencies to cause skin irritation, sensitization, and cross-sensitization in this family of alkyleneamines.