Acetaminophen toxicity up-regulates MRP₂ expression in the liver of cats: an old story with new vision

Abstract

This study was conducted to clarify the role of efflux transporter MRP₂ in acetaminophen-induced hepatotoxicity in cats. Sixteen mixed bred male cats and four liver samples from mixed breed male dogs were used. The cats were assigned into four groups (n = 4), received saline and 2, 10 and 50 mg/kg doses of acetaminophen orally for 14 days. Unlike the intact dogs, the MRP₂ was not detectable in control cats. MRP₂ at mRNA level was expressed in the liver of cats, which received the medium and high doses. Data suggest that the MRP₂ expression may involve in the acetaminophen-induced hepatotoxicity in cats.

• Acetaminophen
• efflux transporter
• hepatotoxicity
• oxidative/nitrosative stress

Declaration of interest

The authors report no declarations of interest.