Toxic effects arising from selenium and deferasirox interaction in the biological system

Abstract

This investigation was conducted to evaluate the effect of deferasirox on selenium toxicity in male rat organs. After 50 days of selenium administration, all the rats showed toxicity symptoms. After poisoning, deferasirox was given orally to rats during 10 days. The results show that toxicity symptoms were unexpectedly increased. The new symptoms of toxicity after deferasirox administration were including loss of body hairs, yellowish discoloration of hair, weakness, brown spot on their skin, enlargement of the spleen and shrinking of sex organs. Selenium and iron concentrations were determined by GFAAS and FAAS, respectively. The results indicate the poisoned rats with selenium that received deferasirox as a drug, shown serious symptoms such as exacerbate toxicity, reduction in iron concentration, anemia and even death after a few days of deferasirox administration.

• Drug interactions
• Exjade
• rats
• selenium
• toxicity

Acknowledgements

The authors are thankful to the head and director of Kerman Neuroscience Research Center for their support of these investigations.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.