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Abstract
Toxic-shock syndrome (TSS) toxin-1 (TSST-1), an exotoxiri produced by Staphylococcus aureus, has been implicated in the development of TSS. The toxin's unique pathobiological properties, including pyrogenicity, ability to enhance susceptibility to lethal endotoxin shock, and alteration of T lymphocyte functions, demonstrated through in vitro and in vivo experimencation, give strong evidence to support the role of TSST-1 as a potent virulence factor involved in the disease process.
In tnis review, we discuss both the biochemical and biological properties of TSST-1 that have been reportea in the literature and recent data fron our laboratory examitling the roles of TSST-1 and endogenous pyrogen (interleukin l) in TSS. Lastly, a model is presented, which defines the role of TSST-1 in the developtnsrit of the illness.