Effect of modifying quantum dot surface charge on airway epithelial cell uptake in vitro

Eric ChauDepartments of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21224, USA

Justin F. GallowayDepartments of Materials Science and Engineering, Chemical and Biomolecular Engineering and Oncology and Institute of Nanotechnology, Johns Hopkins University, Baltimore, MD 21218, USA

Antoinette NelsonDepartments of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21224, USA

Patrick N. BreysseDepartment of Environmental Health Science, Johns Hopkins University, Baltimore, MD, USA

Denis WirtzDepartments of Materials Science and Engineering, Chemical and Biomolecular Engineering and Oncology and Institute of Nanotechnology, Johns Hopkins University, Baltimore, MD 21218, USA

Peter C. SearsonDepartments of Materials Science and Engineering, Chemical and Biomolecular Engineering and Oncology and Institute of Nanotechnology, Johns Hopkins University, Baltimore, MD 21218, USA

Venkataramana K. SidhayeDepartments of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21224, USACorrespondence[email protected]

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Abstract

The respiratory system is one of the portals of entry into the body, and hence inhalation of engineered nanomaterials is an important route of exposure. The broad range of physicochemical properties that influence biological responses necessitate the systematic study to contribute to understanding occupational exposure. Here, we report on the influence of nanoparticle charge and dose on human airway epithelial cells, and show that this platform can be used to evaluate consequences of exposure to engineered nanomaterials.

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Acknowledgements

This work was supported by the FAMRI Young Investigator Award and K08HL085763. JG and PS acknowledge support from NIH U54CA151838. Support for PNB was provided by NSF 0837946.

Effect of modifying quantum dot surface charge on airway epithelial cell uptake in vitro

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Effect of modifying quantum dot surface charge on airway epithelial cell uptake in vitro

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