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Original Articles

Biological impact assessment of nanomaterial used in nanomedicine. Introduction to the NanoTEST project

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Pages 5-12 | Received 04 Feb 2013, Accepted 13 Jul 2013, Published online: 16 Sep 2013
 

Abstract

Therapeutic nanoparticles (NPs) are used in nanomedicine as drug carriers or imaging agents, providing increased selectivity/specificity for diseased tissues. The first NPs in nanomedicine were developed for increasing the efficacy of known drugs displaying dose-limiting toxicity and poor bioavailability and for enhancing disease detection. Nanotechnologies have gained much interest owing to their huge potential for applications in industry and medicine. It is necessary to ensure and control the biocompatibility of the components of therapeutic NPs to guarantee that intrinsic toxicity does not overtake the benefits. In addition to monitoring their toxicity in vitro, in vivo and in silico, it is also necessary to understand their distribution in the human body, their biodegradation and excretion routes and dispersion in the environment. Therefore, a deep understanding of their interactions with living tissues and of their possible effects in the human (and animal) body is required for the safe use of nanoparticulate formulations. Obtaining this information was the main aim of the NanoTEST project, and the goals of the reports collected together in this special issue are to summarise the observations and results obtained by the participating research teams and to provide methodological tools for evaluating the biological impact of NPs.

Declaration of interest

The authors declare to have no relevant affiliation or financial involvement with any organisation or entity with a financial interest or conflict concerning the information presented in this manuscript.

The authors acknowledge the support of the European Commission 7th Framework Programme for the NanoTEST (Health-2007-1.3-4, Contract no: 201335), NanoImpactNet (NMP4-CA-2008-218539, Grant Agreement 218539), NANoREG (NMP.2012.1.3-3, Grant Agreement: 310584) and QualityNano (INFRA-2010-1.131, Grant Agreement: 262163) projects.

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