Metalloproteinases and their inhibitors—diagnostic and therapeutic opportunities in orthopedics

Abstract

Matrix metalloproteinases (MMPs) and related enzymes (ADAMs, ADAMTS) and their inhibitors control matrix turnover and function. Recent advances in our understanding of musculoskeletal conditions such as tendinopathy, arthritis, Dupuytren's disease, degenerative disc disease, and bone and soft tissue healing suggest that MMPs have prominant roles. Importantly, MMPs are amenable to inhibition by cheap, safe, and widely available drugs such as the tetracycline antibiotics and the bisphosphonates. This indicates that these MMP inhibitors, if proven effective for any novel indication, may be quickly brought into clinical practice.

BP did all of the reading and most of the writing. PA served as initiator, supporter, and discussion partner.

BP and PA are co-inventors of a patented method for the coating of sutures with pharmacological agents, e.g. with MMP inhibitors.