Neoadjuvant denosumab for extensive giant cell tumor in os ischium —a case report

Lizz van der HeijdenDepartments of Orthopedic Surgery,Leiden University Medical Center, Leiden, the NetherlandsCorrespondence[email protected]

Michiel A J van de SandeDepartments of Orthopedic Surgery,Leiden University Medical Center, Leiden, the NetherlandsCorrespondence[email protected]

Pancras C W HogendoornDepartments of Pathology,Leiden University Medical Center, Leiden, the NetherlandsCorrespondence[email protected]

Hans GelderblomDepartments of Clinical Oncology,Leiden University Medical Center, Leiden, the NetherlandsCorrespondence[email protected]

P D Sander DijkstraDepartments of Orthopedic Surgery,Leiden University Medical Center, Leiden, the NetherlandsCorrespondence[email protected]

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LH wrote the manuscript. MAJS revised and corrected the manuscript. PDSD operated on the patient and revised the manuscript. HG is local PI for the NCT00680992 study, treated the patient with denosumab, and revised the manuscript. PCWH performed histopathological evaluation of preoperative biopsy and resection specimens, provided images, and revised the manuscript.

No competing interests declared.

Neoadjuvant denosumab for extensive giant cell tumor in os ischium —a case report

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Neoadjuvant denosumab for extensive giant cell tumor in os ischium —a case report

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