Chondrocyte behavior in fibrin glue in vitro

George N Homminga Department of Orthopedics, University Hospital Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands, Tel +31-80 614932, Fax-80 540230

Pieter Buma Department of Orthopedics, University Hospital Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands, Tel +31-80 614932, Fax-80 540230

Henk W J Koot Department of Orthopedics, University Hospital Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands, Tel +31-80 614932, Fax-80 540230

Peter M van der Kraan Department of Laboratory of Rheumatology, University Hospital Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands, Tel +31-80 614932, Fax-80 540230

Wim B van den Berg Department of Laboratory of Rheumatology, University Hospital Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands, Tel +31-80 614932, Fax-80 540230

Abstract

To test fibrin glue as a vehicle in chondrocyte transplantation, chondrocytes, isolated from articular cartilage of young rabbits, were mixed with Tissucol®, a highly concentrated fibrin glue, and cultured for 7 days. Histology, autoradiography (35-S) and electron microscopy were used to study chondrocyte behavior and phenotypic expression. Chondrocytes multiplied, retained their morphology, and produced matrix in fibrin glue as long as the cells were surrounded by the glue. Glue disintegration started after 3 days and was accelerated by higher cell concentrations.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Chondrocyte behavior in fibrin glue in vitro

Information for

Open access

Opportunities

Help and information

Chondrocyte behavior in fibrin glue in vitro

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature