An unusual case of familial ALS and cerebellar ataxia

Sadia Yasser Department of Neurology, University of Texas Medical School at Houston, Houston, Texas

Faisal Fecto Davee Department of Neurology and Clinical Neurosciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

Teepu Siddique Davee Department of Neurology and Clinical Neurosciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

Kazim A. Sheikh Department of Neurology, University of Texas Medical School at Houston, Houston, Texas

Parveen Athar Department of Neurology, University of Texas Medical School at Houston, Houston, TexasCorrespondence[email protected]

Abstract

We report a case of familial amyotrophic lateral sclerosis (FALS) with clinical signs of cerebellar and posterior column involvement. The patient's work-up showed a known mutation (E100K) in the gene for Cu/Zn superoxide dismutase 1 (SOD1). Our case illustrates that extramotor symptoms, such as prominent cerebellar signs, can be seen in patients with FALS.

Key words::

Acknowledgements

Kazim Sheikh is supported by NIH/NINDS (NS42888 and NS54962) grants.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

An unusual case of familial ALS and cerebellar ataxia

Information for

Open access

Opportunities

Help and information

An unusual case of familial ALS and cerebellar ataxia

Abstract

Acknowledgements

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature