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Abstract
In order to investigate the effects of molybdenum (Mo) on sperm parameters and testicular oxidative stress, the ICR strain of adult mice were exposed to different doses of molybdenum for a sub-acute toxicity test. Compared to the control, our results showed that the sperm parameters, including the epididymis index, sperm motility, sperm count, and morphology, increased by a moderate dose of Mo (25 mg/L), but were negatively affected at high doses (≥ 100 mg/L). In addition, the changes of sperm parameters were accompanied with changes of the superoxide dismutase (SOD) activities, the glutathione peroxidase (GPx) activities, and the malondialdehyde (MDA) levels in testes. In conclusion, Mo affects the sperm quality through regulating the testicular oxidative stress in a complex manner.
Acknowledgments
Dr. Chunjie Zhang, Dr. Yinju Li, and Dr. Yumei Liu are thanked for assistance in usage of instruments. Ms. Kerry Alicia Webber is thanked for assistance in preparing the manuscript.
Declaration of interest: This work was supported by the National Natural Science Foundation of China (Project No. 30901026) and the Higher Education Finance Scheme for Young Backbone Teachers in Henan Province (Project No. 2010GGJS-071), China. The authors report no declarations of interest.
Author contributions: Conceived and designed the experiments: F-JL, Z-JY, X-WZ, Y-LZ; Performed the experiments: X-WZ, QQ, YB; Analyzed the data: X-LC, L-JJ, X-GM; Contributed reagents/materials/analysis tools: RS; Wrote the manuscript: F-JL, X-WZ, Y-LZ, RS.