No association of TP53 codon 72 SNP with male infertility: a study in a Chinese population and a meta-analysis

Abstract

Genetic polymorphisms may affect human male fertility. Even though TP53 plays a role in spermatogenesis we know little about the association of the functional polymorphism at codon 72 of TP53 with respect to susceptibility to male infertility. We conducted a case-control study to investigate this association in a Chinese population and performed a meta-analysis in different populations to clarify this association. The single nucleotide polymorphism (SNP) of TP53 codon 72 (rs1042522 G>C) was genotyped by PCR-RFLP in 83 Chinese male infertility patients and 401 healthy controls. Meta-analysis was performed using the data from four currently available studies. The data from our study were overlayed using the v.9.0 STATA software package. We observed no association between the TP53 codon 72 polymorphism and male infertility (p = 0.84, OR = 1.04, 95% CI, 0.74–1.45). Meta-analysis confirmed the case-control result that there was no significant association between the codon 72 polymorphism of TP53 and male infertility (Pro vs. Arg; p = 0.31, OR = 0.86, 95% CI, 0.65–1.15; Pro/Pro vs. Arg-carriers; p = 0.65, OR = 0.91, 95% CI, 0.61–1.36; Pro-carriers vs. Arg/Arg: p = 0.15, OR = 0.75, 95% CI, 0.51–1.11). The data presented in this communication supports the view that the codon 72 polymorphism of TP53 may not contribute to male infertility susceptibility in the Chinese population.

• Male infertility
• meta-analysis
• SNP
• TP53

Acknowledgments

We thank all participants for their participation in this study. Furthermore, we sincerely thank all subjects and all medical colleagues who participated in this study. Many thanks go to the Editor and all reviewers.

Declaration of interest

The authors report no conflicts of interest. This work was financially supported by the Fund of State Key Laboratory of Genetics Resources and Evolution (No. GREKF10-07).

Author contributions

Conceived and designed the study: YC, HJ, YL, WT; Performed the study: YC, HJ, LM, YM, DL; Analyzed and processed the data: JC, YC, WT; Wrote the manuscript: YC, HJ; Revised the manuscript: YC, WT. All the authors read and approved the final manuscript.