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Original Articles

Capsaicin delivery into the skin with lipidic nanoparticles for the treatment of psoriasis

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Pages 33-39 | Received 31 May 2013, Accepted 05 Aug 2013, Published online: 16 Sep 2013
 

Abstract

The study aims to explore the potential of solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) in improving the topical delivery of capsaicin (CAP) by in vitro and in vivo studies. The lipidic nanoparticles were prepared by solvent diffusion method and were characterized for average particle size, zeta potential and entrapment efficiency. TEM photomicrographs revealed that the particles were nanometric in size. Higher amount of CAP can be encapsulated in the NLCs (87.4 ± 3.28) as compared with SLNs (79.7 ± 2.93%). The cumulative amounts of CAP permeated through the skin and retained in the SC were higher in the case of NLCs as compared with plain drug solution and SLNs. SLNs and NLCs exhibited minimum to no irritation. All the results concluded that NLCs and SLNs have shown a good ability to increase drug accumulation in the various skin layers but NLCs may be a more potential carrier for topical delivery of CAP for an effective therapy of psoriasis.

Acknowledgment

The authors are thankful to Colorcon Asia Ltd. for providing the gift sample of CA.

Declaration of interest

The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.

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